Product Name: IL-1alpha Antibody [Bamboo-2] (biotin)
Species Reactivity: Mouse
Tested Applications: ELISA
Applications: ELISA: (as a detection antibody).
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant mouse mature IL-1alpha.
Host Species: Mouse
Purification: >95% (SDS-PAGE)
Physical State: Liquid
CAS NO.: 406-90-6
Product: DEL-22379
Buffer: Liquid. In PBS containing 0.02% sodium azide.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Biotin
Alternate Names: Interleukin-1alpha
Accession NO.: P01582
Protein Ino: 124298
Official Symbol: Il1a
Geneid: 16175
Background: The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
PubMed ID:http://aac.asm.org/content/26/2/266.abstract
