Product Name :
anti-optineurin rabbit mab
Isotype :
IgG
Conjugate :
Unconjugated
Synonyms:
FIP-2, NEMO-related protein, TFIIIA-IntP, GLC1E, HYPL, NRP
UniProt ID :
Q96CV9
Immunogen:
MW (kDa) :
Specificity:
Purity :
Protein A purified
Purity :
PBS, Glycerol, BSA
Storage :
Store at -20°C. Avoid freeze/thaw cycles.
Stability:
Stable for 12 months from date of receipt/reconstitution.
Background :
Optineurin is a signaling protein involved in maintenance of the Golgi complex, membrane trafficking, NF-κB, and interferon signaling. Mutations in the gene encoding optineurin have been associated with human diseases including glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis (ALS). Optineurin is thought to contribute to these pathologies through regulation of inflammatory signaling, autophagy, and mitophagy. The NF-κB-activating kinase/TANK-binding kinase 1 (NAK/TBK1) phosphorylates optineurin at serine 177, regulating optineurin’s role in autophagy and mitophagy. The tumor suppressor HACE1 ubiquitylates optineurin, promoting the interaction of optineurin with the autophagy receptor p62/SQSTM1. Cellular location Cytoplasm, Golgi apparatus, vesicles
Images :
WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:2000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate)Lysate: 1: HeLa, 2: HepG2, 3: A431, 4: NIC-H1299, 5: Human heart Protein loading quantity: 20 μg Exposure time: 60 sPredicted band size: 66 kDa Observed band size: 68, 74 kDa
Vapor Pressure :
Recombinant Rabbit Monoclonal Anti-Optineurin Rabbit mAb Clone Number: JRMR-10439-168 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human Synonyms: FIP-2, NEMO-related protein, TFIIIA-IntP, GLC1E, HYPL, NRP Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms FIP-2, NEMO-related protein, TFIIIA-IntP, GLC1E, HYPL, NRP UniProt ID Q96CV9 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 – 1:2000 Human Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Optineurin is a signaling protein involved in maintenance of the Golgi complex, membrane trafficking, NF-κB, and interferon signaling. Mutations in the gene encoding optineurin have been associated with human diseases including glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis (ALS). Optineurin is thought to contribute to these pathologies through regulation of inflammatory signaling, autophagy, and mitophagy. The NF-κB-activating kinase/TANK-binding kinase 1 (NAK/TBK1) phosphorylates optineurin at serine 177, regulating optineurin’s role in autophagy and mitophagy. The tumor suppressor HACE1 ubiquitylates optineurin, promoting the interaction of optineurin with the autophagy receptor p62/SQSTM1. Cellular location Cytoplasm, Golgi apparatus, vesicles Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:2000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate)Lysate: 1: HeLa, 2: HepG2, 3: A431, 4: NIC-H1299, 5: Human heart Protein loading quantity: 20 μg Exposure time: 60 sPredicted band size: 66 kDa Observed band size: 68, 74 kDa
Recombinant Rabbit Monoclonal Anti-Optineurin Rabbit mAb Clone Number: JRMR-10439-168 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human Synonyms: FIP-2, NEMO-related protein, TFIIIA-IntP, GLC1E, HYPL, NRP Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms FIP-2, NEMO-related protein, TFIIIA-IntP, GLC1E, HYPL, NRP UniProt ID Q96CV9 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:1000 – 1:2000 Human Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background Optineurin is a signaling protein involved in maintenance of the Golgi complex, membrane trafficking, NF-κB, and interferon signaling. Mutations in the gene encoding optineurin have been associated with human diseases including glaucoma, Paget disease of bone, and amyotrophic lateral sclerosis (ALS). Optineurin is thought to contribute to these pathologies through regulation of inflammatory signaling, autophagy, and mitophagy. The NF-κB-activating kinase/TANK-binding kinase 1 (NAK/TBK1) phosphorylates optineurin at serine 177, regulating optineurin’s role in autophagy and mitophagy. The tumor suppressor HACE1 ubiquitylates optineurin, promoting the interaction of optineurin with the autophagy receptor p62/SQSTM1. Cellular location Cytoplasm, Golgi apparatus, vesicles Images WB Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:2000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L (HRP Conjugate)Lysate: 1: HeLa, 2: HepG2, 3: A431, 4: NIC-H1299, 5: Human heart Protein loading quantity: 20 μg Exposure time: 60 sPredicted band size: 66 kDa Observed band size: 68, 74 kDa
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