Os to modify the hydrophobicity of matrix tablet. The matrix tablets
Os to modify the hydrophobicity of matrix tablet. The matrix tablets with single drug have been loaded either with propranolol hydrochloride or hydrochlorothiazide as hydrophilic and hydrophobic model drugs, and also a dual drug formula was also prepared. The single and dual drug release patterns have been studied inside a dissolution apparatus making use of distilled water as medium. Propranolol hydrochloride released from matrix was a lot easier than hydrochlorothiazide. Drug release from shellac wax matrix may be enhanced by incorporation of Lutrol. Nevertheless retardation of drug release from some matrix tablets was evident for the systems that could kind dispersion inside the dissolution medium. The gel network from high content of Lutrol was hexagonal which was a dense and much more compact structure than the other structures located when low amounts of Lutrol have been present inside the formula. Consequently, the formulae with high content material of Lutrol could prolong drug release more effectively than those containing low content material of Lutrol. Therefore shellac wax matrix could modulate the drug release with the addition of Lutrol. Sustainable dual drug release was also SCF Protein Synonyms obtained from these created matrix tablets. As a result shellac waxLutrol element could be used as a possible matrix tablet prepared with fusion and molding method with exceptional controlled drug release. Important words: Shellac wax-Lutrol, matrix tablet, drug release, fusion, molding techniqueControlled release dosage kind is usually a system to provide drug release in an amount adequate to maintain the therapeutic drug level more than extended periods of time, in which the release profile is controlled by unique techniques[1]. The matrix tablet is among the varieties of controlled release dosage form. It really is created to resolve quite a few drawback from the conventional dosage form[2]. The drug release from matrix tablet is mainly controlled by two mechanisms including dissolution control and diffusion control[3]. Having said that, lots of things could influence the drug release profiles which many drug release mathematic models are designed to conceptualize the correct release mechanism[4-6]. The matrix tablet made from waxy material is a great potential for the time controlled release of drug [7]. The wax matrix tablet could be ready by sintering method primarily based on heating the waxy material and blending the other excipients into the molten wax[2].Address for correspondence E-mail: thawatchaienatorgmailSome techniques could be employed to prepare the wax matrix such as hot melt extrusion [8] or injection molding [9,10]. However, these GM-CSF Protein manufacturer strategies compose of a lot of processes and high cost of production. The melting and molding technique is definitely an fascinating and much easier process to prepare the wax matrix tablet[11]. This technique is primarily based on melting waxy carrier and mixing with drug or other excipients before molding and solidifying. Shellac wax (S) obtains from insect secretion of Laccifer lacca. This wax has been located in India, Thailand and also other South East Asia. It really is obtained about 5 as a by-product from shellac manufacturing or collected from a initial melting of crude as initial substance before processing to be shellac [12]. This wax is employed in agricultural manufacture for fruit or vegetable coating[13,14]. In pharmaceutical field, shellac is applied as compression coating for traditional tablet dosage form[15]. Nevertheless the application of S as matrix base for controlled release has not been reported.January – FebruaryIndian Journal of Pharmaceutical SciencesijpsonlinePoloxamer.
