Product Name :
Fosphenytoin disodium
Description:
Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.
CAS:
92134-98-0
Molecular Weight:
406.24
Formula:
C16H13N2Na2O6P
Chemical Name:
disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
Smiles :
[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C2C=CC=CC=2)(C2C=CC=CC=2)C1=O
InChiKey:
GQPXYJNXTAFDLT-UHFFFAOYSA-L
InChi :
InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.|Product information|CAS Number: 92134-98-0|Molecular Weight: 406.24|Formula: C16H13N2Na2O6P|Chemical Name: disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate|Smiles: [Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C2C=CC=CC=2)(C2C=CC=CC=2)C1=O|InChiKey: GQPXYJNXTAFDLT-UHFFFAOYSA-L|InChi: InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : ≥ 100 mg/mL (246.{{NX-5948} medchemexpress|{NX-5948} PROTAC|{NX-5948} Epigenetics|{NX-5948} Technical Information|{NX-5948} Description|{NX-5948} supplier} 16 mM).{{8-Hydroxy-2′-deoxyguanosine} MedChemExpress|{8-Hydroxy-2′-deoxyguanosine} Endogenous Metabolite|{8-Hydroxy-2′-deoxyguanosine} NF-κB|{8-Hydroxy-2′-deoxyguanosine} Technical Information|{8-Hydroxy-2′-deoxyguanosine} Data Sheet|{8-Hydroxy-2′-deoxyguanosine} supplier} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:31970498 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).|Products are for research use only. Not for human use.|
