Product Name: FANCD2 (phospho Ser222) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 166 kDa
Immunogen: FANCD2 (phospho Ser222) antibody was raised against a peptide sequence around phosphorylation site of serine 222 (G-D-S (p)-Q-H) derived from Human FANCD2.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 1542705-92-9
CB-5083
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DKFZp762A223, FA-D2, FA4, FACD, Fanconi anemia
Accession NO.: NP_001018125.1
Protein Ino: 67461071
Official Symbol: FANCD2
Geneid: 2177
Background: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
PubMed ID:http://aac.asm.org/content/40/8/1910.abstract
