Product Name: DEPDC1B Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC-P, WB
Applications: DEPDC1B antibody can be used for detection of DEPDC1B by Western blot at 1 – 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 58 kDa Observed: 57 kDa
Immunogen: DEPDC1B antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DEPDC1B.The immunogen is located within the last 50 amino acids of DEPDC1B.
Host Species: Rabbit
Purification: DEPDC1B antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 293753-05-6
Product: SR3335
Buffer: DEPDC1B antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: DEPDC1B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DEP domain-containing 1B, DEP1B, BRCC3, Breast cancer cell 3, XTP1
Accession NO.: NP_060839
Protein Ino: 223633999
Official Symbol: DEPDC1B
Geneid: 55789
Background: The DEP domain-containing 1B (DEPDC1B) protein was initially identified as a radiation response biomarker in human lymphoblastoid cell lines (1). Like the related protein DEPDC1A, expression of DEPDC1B correlates with a poor prognosis in cancer patients (2,3). Studies have shown that DEPDC1B levels are upregulated in non-small cell lung cancer (NSCLC) and have an inverse correlation with patient survival. Ectopic expression of DEPDC1B in NSCLC activated Wnt/B-catenin signaling and enhanced cell migration and invasion while silencing DEPDC1B expression suppressed these traits (2).
PubMed ID:http://aac.asm.org/content/38/6/1271.abstract
