Product Name: DEFA3 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 10 kDa
Immunogen: This DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the C-terminal region of human DEFA3.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 301836-43-1
Product: D4476
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3
Accession NO.: P59666
Protein Ino: 30316323
Official Symbol: DEFA3
Geneid: 1668
Background: Defensins are a family of microbicidal and cytotoxicpeptides thought to be involved in host defense. They are abundantin the granules of neutrophils and also found in the epithelia ofmucosal surfaces such as those of the intestine, respiratory tract,urinary tract, and vagina. Members of the defensin family arehighly similar in protein sequence and distinguished by a conservedcysteine motif. The protein encoded by this gene, defensin, alpha3, is found in the microbicidal granules of neutrophils and likelyplays a role in phagocyte-mediated host defense. Several alphadefensin genes are clustered on chromosome 8. This gene differsfrom defensin, alpha 1 by only one amino acid. This gene and thegene encoding defensin, alpha 1 are both subject to copy numbervariation.
PubMed ID:http://aac.asm.org/content/38/5/1152.abstract
