Product Name: DEDD2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: DEDD2 antibody can be used for detection of DEDD2 by Western blot at 0.5 to 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.The immunogen is located within the first 50 amino acids of DEDD2.
Host Species: Rabbit
Purification: DEDD2 Antibody is immunoaffinity chromatography purified IgG.
Physical State: Liquid
CAS NO.: 139298-40-1
Product: KN-93
Buffer: DEDD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: DEDD2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DEDD2 Antibody: FLAME-3, FLAME3, PSEC0004, DED-containing protein FLAME-3
Accession NO.: NP_579874
Protein Ino: 19923050
Official Symbol: DEDD2
Geneid: 162989
Background: DEDD2 Antibody: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
PubMed ID:http://aac.asm.org/content/38/5/1134.abstract
