Product Name: DDIT3 Antibody
Species Reactivity: Human, Mouse
Tested Applications: IF, WB
Applications: For FACS starting dilution is: 1:25For WB starting dilution is: 1:2000For IF starting dilution is: 1:10~50
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 19 kDa
Immunogen: This DDIT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of human DDIT3.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 758679-97-9
Product: CID-2858522
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3, CHOP, CHOP10, GADD153
Accession NO.: P35638
Protein Ino: 544022
Official Symbol: DDIT3
Geneid: 1649
Background: This gene encodes a member of the CCAAT/enhancer-bindingprotein (C/EBP) family of transcription factors. The proteinfunctions as a dominant-negative inhibitor by forming heterodimerswith other C/EBP members, such as C/EBP and LAP (liver activatorprotein), and preventing their DNA binding activity. The protein isimplicated in adipogenesis and erythropoiesis, is activated byendoplasmic reticulum stress, and promotes apoptosis. Fusion ofthis gene and FUS on chromosome 16 or EWSR1 on chromosome 22induced by translocation generates chimeric proteins in myxoidliposarcomas or Ewing sarcoma. Multiple alternatively splicedtranscript variants encoding two isoforms with different lengthhave been identified.
PubMed ID:http://aac.asm.org/content/38/4/853.abstract
