Product Name: DDC Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: DDC antibody can be used for detection of DDC by Western blot at 1 – 2 μg/ml.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 53 kDa Observed: 53 kDa
Immunogen: DDC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DDC.The immunogen is located within amino acids 390 – 440 of DDC .
Host Species: Rabbit
Purification: DDC Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1373215-15-6
Product: LY 3000328
Buffer: DDC Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: DDC antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DDC Antibody : AADC, AADC, Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase
Accession NO.: NP_000781
Protein Ino: 4503281
Official Symbol: DDC
Geneid: 1644
Background: DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinsons disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).
PubMed ID:http://aac.asm.org/content/38/4/817.abstract
