Product Name: DC-SIGN Antibody [8B6]
Species Reactivity: Human
Tested Applications: ELISA, IHC-P, WB
Applications: DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 – 2 mg/mL and in immunohistochemistry at 5 – 10 mg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
Host Species: Mouse
Purification: DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Physical State: Liquid
CAS NO.: 1431699-67-0
Product: (S)-Tedizolid
Buffer: DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: DC-SIGN monoclonal antibody can be stored at -20˚C, stable for one year.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: DC-SIGN Antibody [8B6] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Accession NO.: Q9NNX6
Protein Ino: 46396012
Official Symbol: CD209
Geneid: 30835
Background: DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
PubMed ID:http://aac.asm.org/content/38/3/547.abstract
