Product Name: CSEN Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC, WB
Applications: CSEN antibody can be used for detection of CSEN by ELISA at 1:12500. CSEN antibody can be used for detection of CSEN by western blot at 2.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 29 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CSEN.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 24962
Product: 3,3-Diindolylmethane
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store CSEN antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CSEN, CSEN, DREAM, KCHIP3
Accession NO.: NP_038462
Protein Ino: 7305199
Official Symbol: KCNIP3
Geneid: 30818
Background: CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimers disease.
PubMed ID:http://aac.asm.org/content/37/4/908.abstract
