Product Name: CHRNA2 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 60 kDa
Immunogen: This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 179411-93-9
Product: SDZ 220-581 (hydrochloride)
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Neuronal acetylcholine receptor subunit alpha-2, CHRNA2
Accession NO.: Q15822
Protein Ino: 308153405
Official Symbol: CHRNA2
Geneid: 1135
Background: Nicotinic acetylcholine receptors (nAChRs) areligand-gated ion channels formed by a pentameric arrangement ofalpha and beta subunits to create distinct muscle and neuronalreceptors. Neuronal receptors are found throughout the peripheraland central nervous system where they are involved in fast synaptictransmission. This gene encodes an alpha subunit that is widelyexpressed in the brain. The proposed structure for nAChR subunitsis a conserved N-terminal extracellular domain followed by threeconserved transmembrane domains, a variable cytoplasmic loop, afourth conserved transmembrane domain, and a short C-terminalextracellular region. Mutations in this gene cause autosomaldominant nocturnal frontal lobe epilepsy type 4. Single nucleotidepolymorphisms (SNPs) in this gene have been associated withnicotine dependence.
PubMed ID:http://aac.asm.org/content/36/2/372.abstract
