Product Name: CHM Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 73 kDa
Immunogen: This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 60-31-1
Product: Acetylcholine (chloride)
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.27 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, REP-1, TCD protein, CHM, REP1, TCD
Accession NO.: P24386
Protein Ino: 21431807
Official Symbol: CHM
Geneid: 1121
Background: This gene encodes component A of the RAB geranylgeranyltransferase holoenzyme. In the dimeric holoenzyme, this subunitbinds unprenylated Rab GTPases and then presents them to thecatalytic Rab GGTase subunit for the geranylgeranyl transferreaction. Rab GTPases need to be geranylgeranyled on either one ortwo cysteine residues in their C-terminus to localize to thecorrect intracellular membrane. Mutations in this gene are a causeof choroideremia; also known as tapetochoroidal dystrophy (TCD).This X-linked disease is characterized by progressive dystrophy ofthe choroid, retinal pigment epithelium and retina. Alternativesplicing results in multiple transcript variants encoding differentisoforms.
PubMed ID:http://aac.asm.org/content/36/1/227.abstract
