Product Name: CDC25A Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IHC, WB
Applications: CDC25A antibody can be used in ELISA, Western Blot starting at 1:500 – 1:2000, immunohistochemistry starting at 1:100, immunofluorescence starting at 1:200 – 1:1000, and flow cytometry starting at 1:200 – 1:400.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CDC25A antibody was raised against amino acids surrounding Ser 75 of CDC25A (Human).
Host Species: Rabbit
Purification: Immunoaffinity Chromatography
Physical State: Liquid
CAS NO.: 108341-18-0
Product: Norepinephrine (bitartrate monohydrate)
Buffer: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store CDC25A antibody at -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CDC25A, CDC25A2-CAG isoform, Cell division cycle 25A, CDC25A phosphatase, CDC25Hu1, M-phase inducer phosphatase 1, CDC25A2
Accession NO.: P30304
Protein Ino: 50403734
Official Symbol: CDC25A
Geneid: 993
Background: CDC25A, a CDC25 dual specificity protein phosphatase, has been shown to activate the cyclin-dependent kinases at different points of the cell cycle. CDC25A has been shown to affect S phase entry and possibly the initiation of mitosis.CDC25A dephosphorylates cyclin dependent kinases, including Cdk2, Cdk4, as well as non cyclin proteins such as the homeodomain transcription factor cut, the proto-oncogene Raf-1. CDC25A has been implicated in many carcinomas, including those of the colon, lymph node, stomach, ovary, breast. CDC25A is located on chromosome 3p21 in an area frequently involved in karyotypic abnormalities in renal carcinomas, small cell carcinomas of the lung, and benign tumors of the salivary gland.
PubMed ID:http://aac.asm.org/content/35/7/1356.abstract
