Product Name: CD68/CD68 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 37 kDa
Immunogen: This CD68/CD68 (kpi) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the Central region of human CD68/CD68 (kpi).
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 769856-81-7
Product: TPT-260
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Macrosialin, Gp110, CD68, CD68
Accession NO.: P34810
Protein Ino: 147744552
Official Symbol: CD68
Geneid: 968
Background: This gene encodes a 110-kD transmembrane glycoprotein thatis highly expressed by human monocytes and tissue macrophages. Itis a member of the lysosomal/endosomal-associated membraneglycoprotein (LAMP) family. The protein primarily localizes tolysosomes and endosomes with a smaller fraction circulating to thecell surface. It is a type I integral membrane protein with aheavily glycosylated extracellular domain and binds to tissue- andorgan-specific lectins or selectins. The protein is also a memberof the scavenger receptor family. Scavenger receptors typicallyfunction to clear cellular debris, promote phagocytosis, andmediate the recruitment and activation of macrophages. Alternativesplicing results in multiple transcripts encoding differentisoforms.
PubMed ID:http://aac.asm.org/content/35/2/387.abstract
