Product Name: CD40 Antibody [FGK45] (preservative free)
Species Reactivity: Mouse
Tested Applications: Flow, Func
Applications: Functional Application: Activates B and NK cells in vivo and in vitro.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant mouse CD40 fusion protein.
Host Species: Rat
Purification: >95% (SDS-PAGE)
Physical State: Liquid
CAS NO.: 1217022-63-3
Product: PTC-209 (hydrobromide)
Buffer: Liquid. In PBS. Preservative free formulation.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor
Accession NO.: P27512
Protein Ino: 172046819
Official Symbol: Cd40
Geneid: 21939
Background: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkins and Hodgkins lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
PubMed ID:http://aac.asm.org/content/34/9/1803.abstract
