Product Name: CD33 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: CD33 antibody can be used for detection of CD33 by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CD33 antibody was raised against a 14 amino acid synthetic peptide near the center of human CD33.The immunogen is located within amino acids 180 – 230 of CD33.
Host Species: Rabbit
Purification: CD33 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1515856-92-4
Product: XEN445
Buffer: CD33 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CD33 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CD33 Antibody: p67, SIGLEC3, SIGLEC-3, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3
Accession NO.: NP_001763
Protein Ino: 130979981
Official Symbol: CD33
Geneid: 945
Background: CD33 Antibody: CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family that is highly expressed on myeloid progenitor cells. Assessment of CD33 expression is of great importance in the immunodiagnosis of acute leukemia, allowing distinction between myeloid and lymphoid origin, as CD33 is generally restricted to the myelomonocytic lineage. CD33 can associate with the protein-tyrosine phosphatases SHP-1 and SHP-2 and thus could modulate downstream signaling events associated with cell activation. Common variants of CD33 have been found to be associated with late-onset Alzheimers disease.
PubMed ID:http://aac.asm.org/content/34/7/1342.abstract
