Product Name: CD276 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: CD276 antibody can be used for Western blot at 0.5 – 1 μg/mL. Antibody can also be used for Immunohistochemistry at 2 μg/mL. For Immunoflorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 35, 43, 57 kDa Observed: 59 kDa
Immunogen: CD276 antibody was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of CD276.The immunogen is located within amino acids 484 – 534 of CD276.
Host Species: Rabbit
Purification: CD276 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 945667-22-1
Product: Saxagliptin (hydrate)
Buffer: CD276 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CD276 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CD276 Antibody: CD276 molecule, B7H3, B7-H3, B7RP-2, 4Ig-B7-H3
Accession NO.: NP_001019907
Protein Ino: 67188443
Official Symbol: CD276
Geneid: 80381
Background: CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
PubMed ID:http://aac.asm.org/content/34/5/849.abstract
