Product Name: EPHA7 (phospho Tyr791) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 112 kDa
Immunogen: EPHA7 (phospho Tyr791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 791 (A-V-Y (p)-T-T) derived from Human EPHA7 .
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 911222-45-2
Product: LY2603618
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: EHK3, EK11, HEK11
Accession NO.: NP_004431.1
Protein Ino: 146345416
Official Symbol: EPHA7
Geneid: 2045
Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus.
PubMed ID:http://aac.asm.org/content/39/12/2803.abstract
