Product Name: EIF3C Antibody
Species Reactivity: Mouse
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 105 kDa
Immunogen: This EIF3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 538-566 amino acids from the Central region of human EIF3C.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 30123-17-2
Product: Tianeptine (sodium salt)
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3c {ECO:0000255|HAMAP-Rule:MF_03002}, Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03002}, EIF3C {ECO:0000255|HAMAP-Rule:MF_03002}
Accession NO.: Q99613
Protein Ino: 6685539
Official Symbol: EIF3C
Geneid: 8663
Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
PubMed ID:http://aac.asm.org/content/39/7/1632.abstract
