Product Name: EI24 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IHC-P, WB
Applications: EI24 antibody can be used for detection of EI24 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24.The immunogen is located within the last 50 amino acids of EI24.
Host Species: Rabbit
Purification: EI24 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 168021-79-2
Product: NXY-059
Buffer: EI24 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: EI24 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: EI24 Antibody: EPG4, PIG8, TP53I8, p53-induced gene 8 protein
Accession NO.: NP_004870
Protein Ino: 55956766
Official Symbol: EI24
Geneid: 9538
Background: EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
PubMed ID:http://aac.asm.org/content/39/7/1522.abstract
