Product Name: DOK1 Antibody
Species Reactivity: Human
Tested Applications: ELISA, ICC, IF, WB
Applications: DOK1 antibody can be used for detection of DOK1 expression by Western blot at 1 μg/mL. A 62 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 62 kDa
Immunogen: DOK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1.The immunogen is located within amino acids 410 – 460 of DOK1.
Host Species: Rabbit
Purification: DOK1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 223132-37-4
Product: Inolitazone
Buffer: DOK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: DOK1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DOK1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, Docking protein 1, Downstream of tyrosine kinase 1
Accession NO.: AAC51127
Protein Ino: 1848277
Official Symbol: TEP1
Geneid: 7011
Background: DOK1 Antibody: Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.
PubMed ID:http://aac.asm.org/content/38/11/2572.abstract
