Product Name: DNAJC13 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IHC-P, WB
Applications: DNAJC13 antibody can be used for detection of DNAJC13 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 249 kDa Observed: 249 kDa
Immunogen: DNAJC13 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DNAJC13.The immunogen is located within amino acids 1940 – 1990 of DNAJC13.
Host Species: Rabbit
Purification: DNAJC13 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 182004-65-5
Product: KB-R7943 (mesylate)
Buffer: DNAJC13 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: DNAJC13 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DNAJ homolog subfamily C member 13, receptor-mediated endocytosis 8, RME8
Accession NO.: NP_056083
Protein Ino: 112421122
Official Symbol: DNAJC13
Geneid: 23317
Background: DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1). It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2). DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3).
PubMed ID:http://aac.asm.org/content/38/10/2330.abstract
