Product Name: DCTN2 Antibody
Species Reactivity: Human
Tested Applications: IHC-P, WB
Applications: For WB starting dilution is: 1:1000For IHC-P starting dilution is: 1:10~50
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 44 kDa
Immunogen: This DCTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-219 amino acids from the Central region of human DCTN2.
Host Species: Rabbit
Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Physical State: Liquid
CAS NO.: 3520-43-2
Product: JC-1
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 2 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, p50 dynamitin, DCTN2, DCTN50
Accession NO.: Q13561
Protein Ino: 22096346
Official Symbol: DCTN2
Geneid: 10540
Background: This gene encodes a 50-kD subunit of dynactin, amacromolecular complex consisting of 10-11 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation, chromosomemovement, nuclear positioning, and axonogenesis. This subunit ispresent in 4-5 copies per dynactin molecule. It contains threeshort alpha-helical coiled-coil domains that may mediateassociation with self or other dynactin subunits. It may interactdirectly with the largest subunit (p150) of dynactin and may affixp150 in place.
PubMed ID:http://aac.asm.org/content/38/4/733.abstract
