Product Name: DCC Antibody
Species Reactivity: Mouse
Tested Applications: IHC-P, WB
Applications: For WB starting dilution is: 1:1000For IHC-P starting dilution is: 1:10~50
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 158 kDa
Immunogen: This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 86307-44-0
Product: Impurity C of Calcitriol
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Accession NO.: P43146
Protein Ino: 296434474
Official Symbol: DCC
Geneid: 1630
Background: This gene encodes a netrin 1 receptor. The transmembraneprotein is a member of the immunoglobulin superfamily of celladhesion molecules, and mediates axon guidance of neuronal growthcones towards sources of netrin 1 ligand. The cytoplasmic tailinteracts with the tyrosine kinases Src and focal adhesion kinase(FAK, also known as PTK2) to mediate axon attraction. The proteinpartially localizes to lipid rafts, and induces apoptosis in theabsence of ligand. The protein functions as a tumor suppressor, andis frequently mutated or downregulated in colorectal cancer andesophageal carcinoma.
PubMed ID:http://aac.asm.org/content/38/3/588.abstract
