Product Name: Cyclin O Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 39 kDa
Immunogen: Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O.The immunogen is located within the first 50 amino acids of Cyclin O.
Host Species: Rabbit
Purification: Cyclin O Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 226700-81-8
Product: Fosamprenavir (Calcium Salt)
Buffer: Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Cyclin O antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Cyclin O Antibody: CCNU, UDG2, Cyclin-O
Accession NO.: NP_066970
Protein Ino: 153791755
Official Symbol: CCNO
Geneid: 10309
Background: Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this genes product as a cyclin protein family member.
PubMed ID:http://aac.asm.org/content/37/10/2106.abstract
