Product Name: Cullin 4A Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC, IP, WB
Applications: Cullin 4A antibody can be used in ELISA starting at 1:000 – 1:1000, and immunohistochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Cullin 4A antibody was raised against amino acids 1-20 near the N-Terminus of Cullin 4A (Human).
Host Species: Rabbit
Purification: Delipidation and Defibrination
Physical State: Liquid
CAS NO.: 852391-19-6
Product: Necrostatin 2
Buffer: 0.01% sodium azide.
Concentration:
Storage Conditions: Store Cullin 4A antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CUL4A, CUL-4A, Cullin-4A, Cullin 4A
Accession NO.: Q13619
Protein Ino: 108936013
Official Symbol: CUL4A
Geneid: 8451
Background: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 4a is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul4A serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul4A may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Cul4A also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.
PubMed ID:http://aac.asm.org/content/37/8/1649.abstract
