Product Name: CREBL1 Antibody
Species Reactivity: Human
Tested Applications: ELISA, WB
Applications: CREBL1 antibody can be used for detection of CREBL1 by ELISA at 1:1562500. CREBL1 antibody can be used for detection of CREBL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 77 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CREBL1.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 1395084-25-9
Product: MS436
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store CREBL1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CREBL1, CREB-RP, FLJ10066, G13, CREBL1
Accession NO.: NP_004372
Protein Ino: 20631977
Official Symbol: ATF6B
Geneid: 1388
Background: ATF6B (CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6B is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
PubMed ID:http://aac.asm.org/content/37/3/464.abstract
