Product Name: Cortactin (Ab 421) Antibody
Species Reactivity: Human, Mouse
Tested Applications: IHC
Applications: Immunohistochemistry: 1:50~1:100
User Note:
Predicted Molecular Weight: 85 kDa
Immunogen: Cortactin (Ab-421) antibody was raised against a peptide sequence around aa.419~423 (P-I-Y-E-D) derived from Human CORTACTIN.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 86386-73-4
Product: Fluconazole
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: EMS1, IKBA, MAD3, NFKBI, Amplaxin, CTTN, EMS1, SRC8
Accession NO.: NP_005222.2
Protein Ino: 20357552
Official Symbol: CTTN
Geneid: 2017
Background: Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
PubMed ID:http://aac.asm.org/content/36/12/2747.abstract
