Product Name: CLIP170 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, WB
Applications: CLIP170 antibody can be used for detection of CLIP170 by Western blot at 0.5 – 1 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CLIP170 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170.The immunogen is located within amino acids 1340 – 1390 of CLIP170.
Host Species: Rabbit
Purification: CLIP170 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 155206-00-1
Product: Bimatoprost
Buffer: CLIP170 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CLIP170 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CLIP170 Antibody: RSN, CLIP, CYLN1, CLIP170, CLIP-170, RSN, CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1
Accession NO.: NP_002947
Protein Ino: 4506751
Official Symbol: CLIP1
Geneid: 6249
Background: CLIP170 Antibody: CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkins disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
PubMed ID:http://aac.asm.org/content/36/7/1432.abstract
