Product Name: CHRNB3 Antibody
Species Reactivity: Dog, Rat
Tested Applications:
Applications: CHRNB3 antibody can be used for detection of CHRNB3 by ELISA at 1:1562500. CHRNB3 antibody can be used for detection of CHRNB3 by western blot at 0.03 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 53 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRNB3.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 79902-63-9
Product: Simvastatin
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store CHRNB3 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CHRNB3,
Accession NO.: NP_000740
Protein Ino: 4502835
Official Symbol: CHRNB3
Geneid: 1142
Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimers and Parkinsons diseases. nAChRs also play a significant role in nicotine addiction.
PubMed ID:http://aac.asm.org/content/36/2/429.abstract
