Product Name: CD80 Antibody [2D10.4] (PE)
Species Reactivity: Human
Tested Applications: Flow
Applications:
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen:
Host Species: Mouse
Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Physical State: liquid
CAS NO.: 74-55-5
Product: Ethambutol
Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration: 5 uL (1 ug) / test
Storage Conditions: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
Clonality: Monoclonal
Conjugate: PE
Alternate Names: B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1, CD80
Accession NO.:
Protein Ino:
Official Symbol: CD80
Geneid: 941
Background: The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
PubMed ID:http://aac.asm.org/content/35/4/736.abstract
