Product Name: Caspase-1 Antibody [14F468]
Species Reactivity: Gibbon, Gorilla, Human
Tested Applications: IHC, WB
Applications: Caspase-1 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Caspase-1 monoclonal antibody was raised against amino acids 371 – 390 of Caspase-1 (Human).
Host Species: Mouse
Purification: Protein G Column
Physical State: Liquid
CAS NO.: 1357171-62-0
Product: ML228
Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
Concentration:
Storage Conditions: Store Caspase-1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: CASP1, Caspase-1, CASP-1, CASP1 nirs variant 1, Caspase 1, ICE, ICE-like protease, IL-1 beta-converting enzyme, IL-1BC, IL1BC, IL1BCE, p45, IL1B-convertase, Interleukin-1 beta convertase
Accession NO.: P29466
Protein Ino: 266321
Official Symbol: CASP1
Geneid: 834
Background: Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor. Caspase 1, also called interleukin-1 beta converting enzyme, is a cysteine C14 endopeptidase able to process pro-interleukin-1 beta into its active form. Caspase 1 is identical to Caenorhabditis elegans cell death gene ced-3 and may be involved in apoptotic signalling. Inhibition of caspase-1 in mice models extended survival and delayed appearance of neuronal inclusions and symptoms of Huntingdon disease.
PubMed ID:http://aac.asm.org/content/43/5/1256.abstract
