Product Name: CARMA2 Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC-P
Applications: CARMA2 antibody can be used for detection of CARMA2 by immunohistochemistry at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: CARMA2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human CARMA2.The immunogen is located within the last 50 amino acids of CARMA2.
Host Species: Rabbit
Purification: CARMA2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 946518-60-1
Product: LY2409881 (trihydrochloride)
Buffer: CARMA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: CARMA2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CARMA2 Antibody: PRP, PSS1, BIMP2, CARMA2, PSORS2, Caspase recruitment domain-containing protein 14, CARD-containing MAGUK protein 2, Carma 2
Accession NO.: NP_077015
Protein Ino: 332801087
Official Symbol: CARD14
Geneid: 79092
Background: CARMA2 Antibody: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-κB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-κB activation and endoplasmic reticulum stress-induced cell death.
PubMed ID:http://aac.asm.org/content/43/4/960.abstract
