Product Name: Aurora B Antibody [AURKB/1521]
Species Reactivity: Human
Tested Applications: Flow, IF, WB
Applications: Western blot: 0.5-1 ug/mlFlow Cytometry: 0.5-1ug/10e6 cells in 0.1mlIF: 1-2 ug/mlOptimal dilution of the Aurora B antibody should be determined by the researcher.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: Amino acids 89-251 were used as the immunogen for this Aurora B antibody.
Host Species: Mouse
Purification: Protein G affinity
Physical State: Liquid
CAS NO.: 550-83-4
Product: Propoxycaine (hydrochloride)
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Accession NO.:
Protein Ino:
Official Symbol: AURKB
Geneid: 9212
Background: Recognizes a protein of 39-45kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
PubMed ID:http://aac.asm.org/content/53/8/3501.abstract
