Product Name: ERAP1 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IF, IHC-P, WB
Applications: ERAP1 antibody can be used for detection of ERAP1 by Western blot at 1 – 2 μg/ml.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 104 kDa Observed: 105kDa
Immunogen: ERAP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERAP.The immunogen is located within amino acids 730 – 780 of ERAP1 .
Host Species: Rabbit
Purification: ERAP1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 781661-94-7
Product: YM-155
Buffer: ERAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ERAP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ERAP1 Antibody : ALAP, A-LAP, ARTS1, ERAAP, APPILS, ARTS-1, ERAAP1, PILSAP, PILS-AP, KIAA0525, UNQ584/PRO1154, Endoplasmic reticulum aminopeptidase 1
Accession NO.: NP_057526
Protein Ino: 94818901
Official Symbol: ERAP1
Geneid: 51752
Background: The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1), a member of the peptidase M1 family, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). It is also designated as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1) (3). ERAP1 is localized to the lumen of the ER and induced by interferon. It may be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (3,4).
PubMed ID:http://aac.asm.org/content/40/1/230.abstract
