Product Name: EDA Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: EDA antibody can be used for detection of EDA by ELISA at 1:312500. EDA antibody can be used for detection of EDA by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 41 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EDA.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 1092788-83-4
Product: PP121
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store EDA antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: EDA, ED1, ED1-A1, ED1-A2, EDA1, EDA2, HED, XHED, XLHED, HED1, ODT1, ECTD1, EDA-A1, EDA-A2, STHAGX1
Accession NO.: NP_001005609
Protein Ino: 54112101
Official Symbol: EDA
Geneid: 1896
Background: EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
PubMed ID:http://aac.asm.org/content/39/4/976.abstract
