Product Name: ECSIT Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IHC-P, WB
Applications: ECSIT antibody can be used for detection of ECSIT by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.The immunogen is located within amino acids 290 – 340 of ECSIT.
Host Species: Rabbit
Purification: ECSIT Antibody is Ion exchange chromatography purified.
Physical State: Liquid
CAS NO.: 572924-54-0
Product: Deforolimus
Buffer: ECSIT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ECSIT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ECSIT Antibody: SITPEC, Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial, Protein SITPEC
Accession NO.: NP_057665
Protein Ino: 20149633
Official Symbol: ECSIT
Geneid: 51295
Background: ECSIT Antibody: Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
PubMed ID:http://aac.asm.org/content/39/4/953.abstract
