Product Name: E2A (phospho Thr355) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IHC
Applications:
User Note:
Predicted Molecular Weight: 67 kDa
Immunogen: E2A (phospho Thr355) antibody was raised against a peptide sequence around phosphorylation site of threonine 355 (P-S-T (p)-P-V) derived from Human E2A .
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 471905-41-6
Product: MK-0752
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: E12, Tran, TCF3, TFE2, ITF1
Accession NO.: NP_003191.1
Protein Ino: 27777636
Official Symbol: TCF3
Geneid: 6929
Background: E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5- CANNTG-3. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
PubMed ID:http://aac.asm.org/content/39/3/656.abstract
