Product Name: Daxx Antibody
Species Reactivity: Human, Mouse
Tested Applications: IF
Applications: Daxx antibody can be used for detection of Daxx by Western blot at 1 μg/mL. A 120 kDa major band can be detected. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 120 kDa
Immunogen: Daxx antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human Daxx.The immunogen is located within the last 50 amino acids of Daxx.
Host Species: Rabbit
Purification: Daxx Antibody is Antibody is DEAE purified.
Physical State: Liquid
CAS NO.: 63675-72-9
Product: Nisoldipine
Buffer: Daxx Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: Daxx antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Daxx Antibody: DAP6, EAP1, BING2, DAP6, Death domain-associated protein 6, Daxx, hDaxx
Accession NO.: CAG33366
Protein Ino: 48146287
Official Symbol: DAXX
Geneid: 1616
Background: Daxx Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
PubMed ID:http://aac.asm.org/content/38/2/403.abstract
