Product Name: DRAM Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: DRAM antibody can be used for detection of DRAM by Western blot at 0.5 – 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: DRAM antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human DRAM.The immunogen is located within amino acids 170 – 220 of DRAM.
Host Species: Rabbit
Purification: DRAM Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 70288-86-7
Product: Ivermectin
Buffer: DRAM Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: DRAM antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DRAM Antibody: DRAM, DRAM, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator
Accession NO.: AAH18435
Protein Ino: 22450862
Official Symbol: DRAM
Geneid: 55332
Background: DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
PubMed ID:http://aac.asm.org/content/38/12/2908.abstract
