Product Name: DR6 Antibody
Species Reactivity: Human
Tested Applications: ELISA, WB
Applications: DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 68 kDa
Immunogen: DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6.The immunogen is located within amino acids 30 – 80 of DR6.
Host Species: Rabbit
Purification: DR6 Antibody is Antibody is DEAE purified.
Physical State: Liquid
CAS NO.: 415713-60-9
Product: RI-1
Buffer: DR6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: DR6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
Accession NO.: AF068868
Protein Ino: 3549262
Official Symbol: TNFRSF21
Geneid: 27242
Background: DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
PubMed ID:http://aac.asm.org/content/38/12/2877.abstract
