Product Name: DLL4 Antibody [DL86-3AG]
Species Reactivity: Human
Tested Applications: ELISA, WB
Applications: ELISA: (direct and indirect: 1:2,000-1:5,000). Western Blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Recombinant human DLL4 (extracellular domain).
Host Species: Mouse
Purification:
Physical State: Liquid
CAS NO.: 136310-93-5
Product: Tiotropium (Bromide)
Buffer: Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration: 1 mg/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Delta-like Protein 4; Delta4
Accession NO.: NP_061947.1
Protein Ino: 13431490
Official Symbol: DLL4
Geneid: 54567
Background: The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
PubMed ID:http://aac.asm.org/content/38/9/2065.abstract
