Product Name: DIO1 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 29 kDa
Immunogen: This DIO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-57 amino acids from the N-terminal region of human DIO1.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1048973-47-2
Product: MDA 19
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.35 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Type I iodothyronine deiodinase, 5DI, DIOI, Type 1 DI, Type-I 5-deiodinase, DIO1, ITDI1, TXDI1
Accession NO.: P49895
Protein Ino: 182702125
Official Symbol: DIO1
Geneid: 1733
Background: DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3,5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD).
PubMed ID:http://aac.asm.org/content/38/7/1688.abstract
