Product Name: DHH Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 44 kDa
Immunogen: This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 193001-14-8
Product: ZM323881
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Desert hedgehog protein, DHH, HHG-3, Desert hedgehog protein N-product, Desert hedgehog protein C-product, DHH
Accession NO.: O43323
Protein Ino:
Official Symbol: DHH
Geneid: 50846
Background: This gene encodes a member of the hedgehog family. Thehedgehog gene family encodes signaling molecules that play animportant role in regulating morphogenesis. This protein ispredicted to be made as a precursor that is autocatalyticallycleaved; the N-terminal portion is soluble and contains thesignalling activity while the C-terminal portion is involved inprecursor processing. More importantly, the C-terminal productcovalently attaches a cholesterol moiety to the N-terminal product,restricting the N-terminal product to the cell surface andpreventing it from freely diffusing throughout the organism.Defects in this protein have been associated with partial gonadaldysgenesis (PGD) accompanied by minifascicular polyneuropathy. Thisprotein may be involved in both male gonadal differentiation andperineurial development.
PubMed ID:http://aac.asm.org/content/38/7/1548.abstract
