Product Name: Cullin 7 Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC, IP, WB
Applications: Cullin 7 antibody can be used in ELISA starting at 1:000 – 1:1000, and immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Cullin 7 antibody was raised against a peptide near the C-Terminus of Cullin 7 (Human) Amino acids 1679-1698.
Host Species: Rabbit
Purification: Delipidation and Defibrination
Physical State: Liquid
CAS NO.: 109889-09-0
Product: Granisetron
Buffer: Serum, 0.01% sodium azide.
Concentration:
Storage Conditions: Store Cullin 7 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CUL7, Cullin 7, Cullin-7, CUL-7, DJ20C7.5, KIAA0076
Accession NO.: Q14999
Protein Ino: 160370003
Official Symbol: CUL7
Geneid: 9820
Background: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.
PubMed ID:http://aac.asm.org/content/37/8/1659.abstract
