Product Name: Connexin Antibody
Species Reactivity: Chicken, Dog, Human, Mouse, Rat, Sheep, Xenopus, Zebrafish
Tested Applications: WB
Applications: The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 43
Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
Host Species: Rabbit
Purification: Affinity Purified
Physical State: Liquid
CAS NO.: 134624-73-0
Product: Stavudine (sodium)
Buffer: 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Concentration:
Storage Conditions: Connexin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Cx43, Cxn-43, Connexin-43, Cx43
Accession NO.: P08050
Protein Ino: 117708
Official Symbol: Gja1
Geneid: 24392
Background: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
PubMed ID:http://aac.asm.org/content/36/11/2539.abstract
