Product Name: Collagen Type 1 Antibody
Species Reactivity: Bovine, Cat, Dog, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep
Tested Applications: ICC
Applications: Immunocytochemistry: (2.5-10ug/ml). Optimal conditions must be determined individually for each application.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Synthetic peptide (human sequence) corresponding to the C-terminal end of the N-terminal three quarter collagen fragment (Col1 ¾).
Host Species: Rabbit
Purification: Antigen affinity purified.
Physical State: Liquid
CAS NO.: 78110-38-0
Product: Aztreonam
Buffer: Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.
Concentration: 200 ug/ml
Storage Conditions: Stable for at least 1 year after receipt when stored at -20˚C.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: COL1; alpha-1 Type I Collagen
Accession NO.: N/A
Protein Ino: N/A
Official Symbol: N/A
Geneid: N/A
Background: The proteolysis of collagens plays an important role in numerous physiological and pathological situations such as morphogenesis, wound healing, arthritis, arteriosclerosis and tumor metastasis. Triple helical type I collagens are made up of two alpha1 (I) and one alpha2 (I) chains, and are found in skin, tendon, ligament and interstitial tissues. Due to their fibrillary structure native collagens are resistant to most proteases. They are substrates for certain matrix metalloproteinases (MMPs), which constitute a family of zinc-dependent enzymes catalyzing the degradation of extracellular matrix components. Initial MMP-8 dependent cleavage of collagen into the characteristic ¾ and ¼ fragments has been shown to enable MMP-9 diffusion along the protein helix with preferential binding to the collagen ¾ fragment tail. Finally, untwisting of the helix end results in the local denaturation of the triple helical structure.
PubMed ID:http://aac.asm.org/content/36/11/2387.abstract
