Product Name: Chk2 (Ab 516) Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 62 kDa
Immunogen: Chk2 (Ab-516) antibody was raised against a peptide sequence around aa. 514~518 (Q-P-S-T-S) derived from Chk2.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 773-76-2
Product: Chloroxine
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CDS1, CHK2, LFS2, RAD53, hCds1, HuCds1, PP1425, NFKB3, CHEK2
Accession NO.: NP_001005735.1
Protein Ino: 54112407
Official Symbol: CHEK2
Geneid: 11200
Background: The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
PubMed ID:http://aac.asm.org/content/36/1/153.abstract
